Zinc dopamine reddit. " It's a tricky & complicated balance.

Zinc dopamine reddit. So my muscles got tense and I had trouble sleeping.

Zinc dopamine reddit I feel incredible energy, anxiety gone, super social, sex drive sky high. Assuming we're facing weeks, maybe even months without proper access to medication, I guess it's time to dust off a few of those old coping strategies. Having Zinc at the same time as your meds will definitely potentiate Adderall. The dopamine transporter (DAT), a membrane protein specifically expressed by dopaminergic neurons and mediating the action of psychostimulants and dopaminergic neurotoxins, is regulated by Zn(2+) which directly interacts with the protein. Both animal data (Halas and Sandstead 1975; Sandstead et al. This could lead to a higher conversion from Dopamine to Norepinephrine and can be counteracted by supplimenting Zinc. Zinc antagonizes copper - you might be feeling the effects of the copper being stirred up and overstimulating the nervous system. Take it with your adderall for a better peak and easier comedown, or take it as the last adderall is wearing off in order to mitigate the comedown almost entirely. Not only is dopamine important for muscle building benefits, but it can also counteract depression. The question is asking how do people get high when the body doesn't have the resources to provide the dopamine creation the drug triggers. A daily intake of 60 mg of zinc for 10 weeks (10 mg from the diet and 50 mg from a zinc supplement) was associated with a decrease in copper status. Iron – depression is often a symptom of chronic iron deficiency. 20 mg of zinc is very little. minerals: zinc 20 mg, copper 2 mg (10% of zinc amount to prevent copper depletion, although Cu is an oxidant), selenium 100 mcg endogenous compounds: acetyl-carnitine (ALCAR) 1000 mg, lipoic acid 600 mg, ubiquinol (CoQ10) 100 mg, beta-alanine 1600 mg Probably not. Jan 16, 2025 · Yes high serum zinc and low serum copper and ceruloplasmin. Do you mean dopaminergic drug addiction? You can't be addicted to dopamine, part of addiction involves dopamine dysfunction that usually arises from illness, environmental pollution, or most commonly, drug abuse. In addition, zinc supports one of the fundamental ingredients for mental health — dopamine. Copper and Zinc are Antagonists, a lot of stress and depression can deplete Zinc. Novos labs longevity protocol says to take them separately because they compete for similar pathways. Neurotransmitter Imbalances, Acetylcholine, Gut-Brain Axis, Methylation Imbalance, Pyrrole Disorder, Elevated Copper Levels, Zinc Deficiency, Iron Deficiency, Magnesium Deficiency, Omega-3 Fatty Acids, Vitamin D Deficiency, Glucose Dyscontrol (Potential byproduct) Are you sure that's the problem? If you absolutely are sure, then check your zinc/copper levels. When taking high dose zinc (like 100mg elementary zinc) directly afterwards, the swallowing and the me A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain. Prolactin is known as the anti dopamine hormone so more dopamine offsets it's crap. Copper is good for dopamine/adderall motivation and your stack, combined with adderall, will eventually deplete that as well. Increased dopamine receptor density is not necessary for the upregulatory action of Bromantane. ND micronized zinc causes me no nausea at all even when i take it on an empty Get the Reddit app Scan this QR code to download the app now Zinc can cause a one-time spike in dopamine levels if you've been mildly or moderately deficient. I started taking a zinc+copper supplement and felt more energy at first, but quickly become overloaded in copper and became extremely irritable. . 5-HTP is essentially toxic in this regard, as tryptophan->serotonin has extra rate limiting My symptoms are high dopamine (tested), depression, anxiety, insomnia, OCD tendencies, focusing issues, daytime fatigue, and I'm good at learning new things. Copper supplementation is necessary to prevent deficiency when supplementing high dose zinc, however at 30mg zinc per day you should be fine. There are a number of ways zinc does this, but some of these include: •prevents your brain from becoming overexcited at NMDA receptors •helps create/regulate serotonin, GABA, dopamine •increases BDNF According to Trudy Scott, the zinc taste test can help determine if you need zinc! Google it! Zinc is a surprisingly effective supplement as well, and actually is a subtle dopamine re-uptake inhibitor. Ive taken zinc citrate at 25 mg/day for about 2 months, I was doing 50 mg but I was having nausea immediately after taking it so I cut back to 25. The study is specifically with cocaine addicted mice, and basically zinc made them do more coke than usual (presumably because it made it better, dopamine is the best part of coke). It wasn't until Kent C Berridge and others started doing experiments to see what happens to the "liking" response when you blockade dopamine that we discovered that dopamine has no apparent role in this pleasure sensation! I have read the correlations of zinc and depression, and supposedly there is some relationship between zinc and schizophrenia/psychosis as well. Improperly balanced administration of serotonin and dopamine precursors (Figures 1 and and2)2) leads to decreased efficacy and increased incidence of side effects. Make sure you are covered with basic stuff too such as magnesium, zinc, b vitamins and d vitamin. I’ve done this and it’s worked great but… I was wondering what are some other ways you can increase your dopamine naturally ? I’m really struggling to focus these days even though I’m on The symptoms of Autism include a lack of willingness to make eye contact, repeated tasks etsWhich some studies were ameliorated with glycine, arginine, zinc, and creatine ( I can't find the study at the moment)My current stack is: Lysine, acetyl L carnitine, COQ10, Zinc, selenium, vitamin C and Iron ( every two days) and probiotics It's fairly well known that excess zinc can cause neurotoxicity; it "looks" like copper that is needed in neuron function, and increased zinc can cause an effective copper deficiency. The only time to take extra zinc would be at the onset of cold/flu symptoms, and that’s only to lessen the severity/length of the cold/flu. I don’t get how people actually benefit from it. It keeps my ratio where it needs to be, and I've only ever struggled with zinc deficiency not copper. Keep in mind you also get zinc from foods as well, so you are likely overdosing on zinc without even realizing. Elevated zinc decreases copper. Zinc increase dopamine and testosterone and both can increase arousal even in non deficient people . "The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. I suppose if enough copper is taken it'd be okay as long as the zinc intake wasn't unusually high. “In noradrenergic neurons, Cu is needed for activity of dopamine-β-hydroxylase (DBH), which converts dopamine to norepinephrine and is required for catecholamine balance” “Cu is required for myelination of neurons [ 13 ], and it influences synaptic transmission by modulating functions of GABA and NMDA receptors, as well as voltage-gated Here are some reasons why zinc could work for social anxiety or hesitation: Zinc deficiency and anxiety: Low levels of zinc have been linked to symptoms of depression and anxiety. B1 can also be related to anxiety. Since going hypomanic will drain my serotonin and dopamine (more so with my ADHD). Dopamine releasers cause euphoria in high doses and therefore might pose a risk for people with addictive personalities. Dopamine reuptake inhibitors, on the other hand, are unable to cause euphoria, even if they are injected in very high doses. e. Also giving blood to remove iron due to iron overload in body. “Lithium decreases presynaptic dopamine activity and inactivates postsynaptic G protein” (1;2) Norephinephrine: Further down the dopamine conversion chain, lithium also decreases this catecholamine, which is also part of “overmethylation”. It got rid of my anhedonia, depression, anxiety and what I thought was permanent sexual dysfunction caused by SSRI treatment. Mineral supplements, including the one OP shared, denote the elemental Zinc amount. Zyban. g setting up little simple and achievable tasks and completing them. Copper is required to convert dopamine to epinephrine and norepinephrine. Zinc has completely changed my life. The fact that you are vegan won t make you automatically deficient in zinc if you eat legumes and nuts. I got my levels back a few weeks ago and they are 10 umol/L (or 65 ug/dL). Zinc is involved a great deal in the synthesis of neurotransmitters though. You end up in higher dopamine state after DBM inhbition. With the popularity of Vitamin C and Zinc as supplements, I would say Zinc overload/toxicity and Copper deficiency are probably more common than Copper toxicity. Zinc and iron blood levels of at least 100. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are now allowed as responses to this comment. I just today realized what a dopamine loop is and I want supplements to help me as I make strides to turn my life around. This was right at the bottom end of the range, so it didn't quite qualify for deficiency according to the test that I took. On a quest for clarity, motivation, vitality, your goal is to keep a solid dopaminergic tone and as little serotonin, the hibernation neurotransmitter, as possible. These support the metabolic pathways for serotonin and catcecholamine synthesis (dopamine, noradrenalin, etc) yes. zinc makes me feel like I'm going to die. Have had that experience with both Vyvanse and Dexamphetamine Dopamine based stimulants will deplete your Sodium levels so make sure you're getting enough of your electrolytes; Sodium, Potassium etc. I started taking 50 mg of P5P at my doctor's recommendation in order to increase dopamine; B6 is a major cofactor for speeding up the enzyme that converts l-dopa to dopamine but also histidine to histamine. He suggests that ADHD medications like Vyvanse increase the available dopamine, enhancing alertness and focus, but don't necessarily boost dopamine production. Helps Produce Dopamine. I am impressed with Nootropic's Depot Micronized Zinc. ) If your Co/Zn ratio is high noradrenaline increases and dopamine decreases. Excess copper leads to higher epinephrine production, tanking dopamine. Coke inhibits dopamine reuptake, zinc potentiates the effects of dopamine, either by acting presynaptically to increase dopamine levels or postsynaptically as some sort of cofactor (unsure, didnt read article, just going based off logic here) therefore making coke use more pleasureable. 😊 We discuss the wonderful ways the autistic brain functions! Dopaminergic Neurotransmission. There has been many studies showing the efficacy and the reason quercetin works so well is that it is a zinc ionophere. According to a 2021 study, zinc helps elevate levels of brain-derived neurotrophic factor (BDNF) in the areas of our brain that control our emotions. My zinc levels have always shown as low (not deficient, but kinda borderline). Evidence of this speculation is found with the shared symptoms that result from individual nutrients that have similar effects on specific neurotransmitters (ex. Your symptoms sound like adrenal dysfunction to me. More motivation, happier and all-round better mood. I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. conformational change). Zinc enhances dopamine, serotonin, bdnf, testosterone and anti-inflammatory signaling, while helping as an antioxidant and nmda-antagonist. A plausible explanation is that 5-10% of people of sensitive to supplements and can have strong reactions. Anger and irritability occur with excess dopamine. All 3 need to be at optimal levels to make dopamine, per Dr Amen the brain doc. Zinc is a good supplement for a lot of people, especially men (it is required for testosterone production), and a lot of people are deficient in it. edu Dopamine-β-Hydroxylase has 2 cofactors copper and Vit C. A common long term side effect for ashwaganda is reported to be anhedonia. " It's a tricky & complicated balance. People report the same when taking too much l-tyrosine, a precursor to dopamine, which is also my experience. Why would this be beneficial if schizophrenia correlated with high dopamine in which zinc supplementation would only increase further? The enzyme that converts dopamine to norepinephrine (dopamine beta-hydroxylase) has cofactors of copper and vitamin C. The only one that I know of is extract from Nightshade plant. Zinc binds to the dopamine transporter and slows it down, allowing dopamine to remain active in the synapse for a longer period of time before being pulled back into the cell to be recycled. You need to have a baseline stimuli free of bombardment. If both occur at the same time, though, Amphetamine could deplete dopamine stores faster. Igennus Neurobalance is a lifesaver. 8 mg zinc/kg [21, 68], similarly, we utilized the following diets: zinc-deficient 3 mg zinc/kg; zinc-adequate 50 mg zinc/kg , the study which did I had via blood test confirming that my zinc levels were on the low end and my doctor wants me to get mine up. [PARKINSON'S] Elevated copper lowers dopamine levels and increases norepinephrine in the brain. Vitamin B6 P5P form - Required for both serotonin and dopamine Zinc Picolinate - but be careful - you can take too much. I'm MTHFR heterozygous (confirmed by testing) and I am pretty sure I have a slow COMT gene (haven't tested yet, but I have many symptoms, such as high tonic dopamine confirmed by urine tests, overthinking, insomnia, I'm very organized with my things, have great attention to details, etc. Take 1g a day. Can attest myself after several years on and off. That's why it's a common ingredient in pre-workout formulas. The bioavaliabilty of zinc supplements is very low, as little as in the teens depending on type, and the all vary. This way, simple things will give you the dopamine boost. Edit: It does do that through increasing the testosterone level, through this combination. Dopamine addiction is not a thing. There are no studies that point to an increase in dopamine or noradrenaline due to concurrent zinc supplementation. Dopamine is a neurotransmitter involved in the motivation and reward pathways. Furthermore, zinc supplementation is well known to boost testosterone. It is essentially a natural “dopamine reuptake inhibitor. 1g of Yerba mate contains around 8-10mg of caffeine. BUT: When you first start taking zinc, it might make you feel like it's having the opposite effect. need copper to transport iron, iron is used to create l-dopa, which gets converted to dopamine. Most importantly, if only one precursor of If you take Zinc and already have a high copper level, it does do that. Zinc can cause anxiety in other ways too; reduced DHT (if you take too much), reduced copper levels (copper's involved in the dopamine system) and low estradiol/estrogen. Anyways, stick with those precursors and then stay off of tv and your phone. But once I pass the dopamine withdrawal of stopping my meds or supplements, I feel my personality come back, I feel so much more crazy and wild thinking and more quick witted. to get 20 mg of zinc can take upwards of 200 mgs of zinc supplements and if your doing that then throw in some copper IT is a rate iimited dopamine precursor. Tracking micro's in Cronometer I'm hitting my RDA without supplementation. Certain pairs of things need to be kept balanced in the body, such as zinc-copper or dopamine-serotonin. I think people should search for and read the studies instead of believing the bro- nonsense that they read on reddit. Stress in my life is high however, sleep is average as a norm also. According to this study, 30mg elemental zinc daily for 13 weeks (final five weeks used alongside D-amphetamine) was able to reduce the amount of D-amphetamine that was needed by 37% and reduced affective blunting from 21% (placebo with amphetamine) to 11%. Keeping in mind a lot of things can be synthesised naturally, others can only be found from diet or the sun (I’m brown so I don’t absorb vitamin possible its the zinc supplement reducing supply of tyrosine. As a neurotransmitter, dopamine enables the mind and muscle to work together, increasing the benefits that occur from weightlifting. I've read that Zinc Picolinate is the most bioavailable form. The enzyme that converts L-DOPA into active dopamine, L-dopa decarboxylase, is a pyridoxine-5'-phosphate (PLP) dependent enzyme and due to the actions of pyridoxine infusion paralleling that of dopamine (in regards to prolactin and growth hormone) it is thought that additional pyridoxine increases the activity of this enzyme particularly in the hypothalamus. Low zinc is directly related to anxiety. So it is 50mg elemental Zinc; not 7. Obviously 30 mg is less than the 50 mg tested in the study and is also within the upper limit dose of 40 mg of zinc a day for adults outlined by The National Institutes of Health. Actually, if you want to raise your dopamine, drinking coffee or yerba mate is probably one your best bets. Results of previous reports regarding the relationship between zinc levels Posted by u/TheInvisibleFeet - 1 vote and no comments My parents didn't place much stock on it, who needs zinc right, certainly not a 6 year old! I've honestly felt better on Zinc and Iron supplements, my severe PMS almost vanishes, my mood improves, I don't suffer frequent burnouts, I'm more focused and I'm not fatigued. So it looks like the Tory government and our crumbling health service have comprehensively hung us out to dry. But after a bit, I’m like, man I need to figure out how to focus better and be more productive. And if you’re a lady you already lose a ton of them from your period, especially iron which not only controls thyroid hormone (super necessary for brain function) but is Welcome to r/science!This is a heavily moderated subreddit in order to keep the discussion on science. That's how my diagnosing clinician explained it to me. Copper is only supplemented alongside zinc sometimes as zinc depletes copper in your body, Not to be pedantic, but zinc inhibits absorption of copper, it does not deplete the body's store of copper. Norepinephrine–dopamine reuptake inhibitor (NDRI) , major depressive disorder, atypical antidepressant , Epileptic seizures , ADHD, alleviate sexual dysfunction, weight loss, releasing agent of dopamine and norepinephrine (NDRA), similarly to other cathinones , Wellbutrin SR and XL There’s a couple groups that are promoting copper due to deficiencies. Zinc is essential to testosterone production, but I’m mostly taking it for skin heath, which it seems to be helping with. Cocaine appears to lower your zinc levels, that's why supplementing seems to help. Just a guess, probably a combination of things. Manganese – this metal is needed for proper use of the B-Complex vitamins and Vitamin C. Does Zinc have an affect on neurotransmitters? I've recent been taking Maca and the effects have been huge for me. Whereas the two studies in which increased immobility time in the FST following 2 weeks of the diet utilized the zinc-deficient diet containing 0. Stop doing those first and your dopamine will come back and cortisol will lower. I did seem to have an increase in mood (or I should say a reduction in negative mood), but noticed I was putting on water weight. 1977; Golub et al. Only problems with supplementing high levels of zinc is the possibility of interfering with the normal functioning of iron and a depletion of copper. The link is strong enough that the degree of zinc deficency can accurately predict the severity of depression. 30mg elemental zinc appears to be slightly effective as an addition to D-amphetamine therapy. Anyway, although it might be fine to use short-term in a targeted way, 50mg Zinc is definitely too much for long-term use. Drugs like ecstasy or molly blow all your dopamine levels and take many days to replenish. Males need a little bit of estrogen, drive levels too low and anxiety is one of the possible symptoms. I previously have never been able to take standard zinc supplements too often as they usually always cause me to get nauseated. Zinc levels and zinc supplementation seems to be a big thing in nutritional psychiatry. lions mane most recently messed me - similar feelings to that of taking zinc but worse! and lasted for days. You can find studies where taking 3 mg of zinc daily reduces the amount of dexamphetamine you have to take to get the same results by 30 %. The Example: daily iron runs the very high risk of constipation/nausea in addition to eventually causing zinc deficiency (which is actually very hard to measure because blood tests aren't very reliable). I'm extremely sensitive to increases in dopamine because of some weird neurological problems I have. couldnt hurt to eat some foods with alot of copper such as pistacchios or cashews The human dopamine transporter contains a high affinity extracellular zinc binding site which, upon zinc binding, inhibits dopamine reuptake and amplifies amphetamine-induced dopamine efflux in vitro. noticed after 4 months of zinc supplements, didnt make the connection between that and the zinc until years later. 9mg for adults. I do feel somewhat better on the choline, but nothing too noticeable, despite having taken it for so long. What others do YOU know? Little educational post attempt here, let's all share our knowledge on this to help each other out. Zinc – inadequacies result in apathy, lack of appetite and lethargy. So my muscles got tense and I had trouble sleeping. That along with too much cortisol. so awful. This community is focused on neuroscience research of how autism, ADHD, OCD, schizophrenia, schizoaffective etc presents in women. Thereby, EMF elevate copper, decrease dopamine and elevate norepinephrine. In laments terms the meds bind with dopamine receptors and allow a dopamine molecule to bind multiple times before breaking down. B9, Vitamins B3 (Niacinamide) and B12, Zinc, Choline, DMAE, manganese (reduces dopamine synaptic activity), zinc, P5P(B6) which increase GABA, Vit. Sleep well, eat well, go out in the sun and exercise. Copper citrate works best for me. ZMA is not really a good product. It is also anecdotally reported to give people vivid dreams and a significant increase in appetite, 2 effects commonly seen in people who use dopamine agonists. https://www. 4/ Zinc deficiency - causing low serotonin, low zinc, and oxidative stress I advise against taking any type of multivitamin or B complex as some vitamins in the mix can be counter indicated eg) choline is antidopaminergic, folate reduces serotonin and dopamine, copper causes dopamine to convert to noradrenaline etc. Zinc, b6, and vitamin c. Watch his video on dopamine and the analogy of the tidal wave pool. You should also know that studies show that eventually depletes dopamine and then leaves your serotonin as low as before treatment. So, upping your zinc could have fixed that as they are competitive. EMF depletes zinc and elevates cortisol which elevates copper. But dopamine is stimulatory, so you might just have high dopamine. Quercetin , zinc , vitamin c are a very potent combination to fight of virus’s. Also consider also using topical DIY Zix for further non systemic topical DHT reduction. The RDA for Zinc is 11mg daily for adults, and the RDA for Zinc is 0. C & E Should strictly avoid supplements containing copper, methionine, SAMe or SSRI’s Lab Tests: Whole Blood Histamine CPT #83088, Homocysteine CPT #83090 (Overrmethylation Lab Panel) A few weeks ago I started formulating a dopamine depletion theory posted here and started taking DLPA (D,L-Phenylalanine) in hopes of increasing the dopamine levels in my body. I suggest the glycinate form. This will sound retarded but stop ejaculating. Zinc inhibits prolactin in the CNS, increases thyroid hormone activity and antagonizes NMDA receptors. Also there are distinct metabotropic receptors that bind zinc in the brain and an immediate search pulls up a journal article that mentions it has interactions with AMPArs and 5HT1Ars + mTOR among other places. On a side note, I’ve tried zinc for many years and always had to come off because it would cause side effects. Nor does zinc do anything for ADHD if you are not deficient in the mineral. source. I am also doing dopamine detox at the moment and I also would like to share a part of my experience so far. Hello everyone, In the episode about dopamine,Huberman says that you can raise your base line “wavepool” of dopamine by taking a cold shower. Nicotinic acid helped immensely too. nlm. just awful. Welcome to the Nootropics Australia subreddit! Our community is devoted to discussing the latest advancements in nootropics and cognitive enhancers, such as Piracetam, Aniracetam, Choline, Modafinil, Caffeine, and more. I would strongly recommend trying those before trying SAM-e. " I'm more concerned with longer term zinc intake raising metallothionein. Amen low dopamine is related to attention problems. There’s 2 camps that vary in some of the subtleties but they’re both pro copper, iodine, b vitamins, real vit C and then it seems to vary on zinc & other minerals supplements depending on your body make up and general health. When you get your dopamine, research increasing dopamine receptor density. They might be better for people with addictive personalities. " Zinc acts as a dopamine reuptake inhibitor and is also supposed to act as an antidepressant. "Zinc regulates the dopamine transporter in a membrane potential and chloride dependent manner. I think It's a combination of lack of sleep plus depression. Jul 16, 2021 · Zinc is involved in melatonin production which modulate the function of dopamine and facilitate dopamine signaling 11. Using co-forms of zinc that have other uses in the body like zinc sulfate, (which you are) and zinc glycinate instead of zinc picolinate or zinc gluconate is superior as picolinate & gluconate are worthless binding agents once cleaved from the zinc in digestion. But i would also advice against taking so much zinc in one dose. So much so that I decided to log into reddit and post a review (which i never do). Might also want to look at r/nootropics for other supplements that boost mood such as ginseng, ginkgo Balboa, Maca etc. Prolactin is usually inversely correlated with dopamine and can also lower lh / fsh resulting in lower testosterone. Then to take 3 supplements to aid in sleep, and serotonin and dopamine production. That is how you start feeling those weird feelings. Potassium – depletion is frequently associated with depression, tearfulness, weakness and fatigue. That is an excrept from Wikipedia. Still, both are significantly different than what is in the brand you have been taking. That is made of distilled water, ethyl alcohol, zinc sulfate and b6 p5p This "liking" expression was once thought to be a result of dopamine concentration in the nucleus accumbens. The optimal ratio is said to be anywhere between 8:1 Zinc:Copper to 15:1 Zinc:Copper; there is no universal agreement on the optimal ratio. Folate upregulating production of dopamine and zinc inhibiting dopamine reuptake; the result being the same negative feeling). Zinc increases dopamine. This is without accounting for excess consumption of Vit C and Zinc. ” Specific to ADHD, the dopamine transporter has a zinc binding site that blocks transport (Lepping and Huber 2010). If you have hidden copper toxicity - excess copper stored in the tissues (i. Last time this happened only time fixed it. Each and every time I supplement with Zinc at night I the day following is always a good day. This is actually why they stopped putting zinc into denture paste, lots of older adults were getting a zinc-induced myelopathy. (Over 80%) You can find liquid zinc sulfate on Amazon for like 15-20 bucks. Zinc will regulate copper levels. Excess copper converts your dopamine to norepinephrine, I felt psychotic and it took a couple of days supplementing zinc alone to feel normal again. ). After around 30-45 min of ingesting 500 mg tyrosine, i get depressed, irritated and have issues with swallowing water or food. Zinc is also said to be stimulating as it is possibly a weak dopamine reuptake inhibitor. I'm finding myself with an extreme lack of motivation and seeking extreme amounts of short-term dopamine rushes that is become detrimental to my life. I had a very similar experience in terms of my productivity and my attention span but I must point out that if you are not stressed or comfortable with your life in general it is not so hard to keep up with this challenge. But vitamin c and tyrosine. It helps enhances neurological recovery by proliferative means such as promotion of angiogenesis and is known to help skin disorders such as acne. Magnesium Glycinate - 400-600mg / day split over day. Just off hand I can recall a zinc taste acuity test double blind 300 participant's that also took zinc blood plasma lvls and found the zinc taste test to be pretty damn accurate. Apparently (too much) zinc can affect brain dopamine binding, you can research this by googling zinc dopamine. It's actually not necessarily paradoxical - Zinc potentiates dopamine release by Amphetamine (through DAT allosteric modulation), but at the same time, it might also decrease dopamine production (through inhibition of iron binding to TH). After using L-Tyrosine for low dopamine, i had some side effects which i couldn't connect to the tyrosine. In all honesty, it probably only makes a difference if you're a regular user. Also per Dr Amen in order for a person to make dopamine you need optimal levels of zinc, iron and D. 37 mg zinc/kg and the zinc-adequate diet containing 52. The original formula consists of mag aspartate, and aspartate is excitatory. My mother took it (because her doctor told her to) when she was dying from cirrhosis of the liver. I don’t know exactly how it does it even though it does increase dopamine in the short term, but the side effect is is common enough it’s become a trend among teens to use it as a way to become apathetic. Different dopamine receptors can have opposite effects depending on their location in the synapse (pre- or post- synaptic) or in different brain regions. DBM normally converts dopamine to norepinephrine. My sensory processing sensitivities become more manageable. Also there’s zinc lozenges and cold medicine! Edit: missing word This suggested that the zinc supplements decreased the copper status of the experimental group. D of 80. liver, kidneys, brain), then that be affected by taking zinc. Maybe your getting a bump in some of the more stimulating ones. Dopamine is considered to be associated with tons of other effects that have to do with the bigger result of pleasure/euphoria and also more random ones, such as anticipation, repeating behavior, muscle contraction, and more; essentially it plays a big role in the cycle/process of the concept of "reward". So then someone will say oh just take zinc but that will then decreases iron and copper absorption because they compete during intestinal absorption. anxiety, can't feel my body, brain fog - like I'm stuck in quicksand. I use zinc, b6, and tyrosine for anti prolactin. E. Per Dr. Dopa, a precursor of dopamine is oxidatively produced from tyrosine by the copper enzyme tyrosinase. If a brand is doing otherwise, it is a really weird brand. Feel amazing after pmo as opposed to depressed, with brain fog etc. It is Zinc Picolinate split into 6mg doses, which makes it easier to spread out through the day, insuring higher absorption (you can only absorb about 7mg of zinc in a go IIRC), and less risk of a supplement-induced copper deficiency, as the doses are small enough not to trigger the pathways that reduce metal absorption. iirc zinc has positive effects on dopamine signaling. Sohomocysteine, folate, b12, D, zinc, iron, B6 and B1. hydrophobic), whereas for dopamine re-uptake inhibitors it is enthalpy-driven (i. I took 40 mg of combined zinc biglycinate + zinc picolinate, and I have seen a pretty alarming decline in work motivation. So I read online zinc improves dopamine processing in Autism because it balances copper which is elevated in ASD. All this is good, but the problem is that while zinc is the signal for producing metallothioneins, these proteins bind to copper better than they do to zinc. Prolactin is released afterwards and will make you feel tired by reducing dopamine, and it accumulates in your blood over time too. In general, it was like drinking too much caffeine. Zinc promotes gaba production (aswell as glycine) this competes with dopamine and can lower dopamine causing irritability and anger if you are already low! You can try to offset this by taking tyrosine which increases dopamine! Summary: Bromantane increases dopamine synthesis, balances excitatory and inhibitory neural networks, and increases neurotrophins by reducing neuroinflammation through epigenetic mechanisms. I’m just adding the ingredients to either restore my serotonin and dopamine levels or increase gene expression. This is a good thing, as it prevents zinc toxicity. This is where these precursors come in. ncbi. So I tried it out as I felt myself shutting down / dissociating and it actually worked! Anyone else tried this and noticed it helps? So now I take it every 4 days and it works wonders. NAC is supposed to flatten you out, so helps downscaling mania and upscaling anhedonia, as it works as a sort of glutamate modulator. B6 as pyridoxine HCL is garbage, and P5P can also be stimulating. Magnesium is helpful. In essence, there really is known storage of copper within the body as evidenced by rapid depletion with copper-restricted diets. α-Amidating monooxygenase (α-AE), also called peptidylglycine α-AE, uses copper and ascorbate to remove two car- bons from a C-terminal glycine of peptides, thus generating an amide. I think zinc is known to boost dopamine for one which would 100% cause a rise in anxiety. Zinc plays a large role in how we react to stress and deficiency is linked to depression. These epithelial cells shed every 5-6 days, and the metallothioneins with their bound excess zinc are shed too, and excreted in feces. If you want to really go in on this, add a base for the morning and add copper to your stack to prevent depletion due to zinc, vitamin C, and adderall. nih. For example, a Harvard article titled "Nutrition's dynamic duos" discusses the effects of high amounts of zinc causing copper deficiency so they recommend adding copper to zinc supplements. Ate 2 lbs of beef + 25-50mg zinc bisglycinate, so roughly 65-90mg total zinc intake. Your common SSRI that is probably the most effective is St. careful if you're on birth control - because birth control is very very high in copper and zinc will just try to knock it all out of you. I cut one 25mg pill to half and take a half every day, that’s all you need. gov/pubmed/19000913?dopt=Abstract Wanted to add dopamine beta-hydroxylase (aka dopamine beta-monooxygenase. And also fasting Zinc plays a big role in neurotransmitter synthesis. May in my case would be worth trying aswell, one of the most basic approeches. According to this study, high dose Zinc supplementation (60ppm in drinking water, equal to 60mg per day in humans) does not change brain zinc at all: Mice fed high dietary zinc showed significantly increased zinc level in serum and hemocytes, but the total brain zinc level was not changed. Dopamine: Mucuna pruriens. Quercetin helps transport zinc into the bodies cells and makes the zinc very effective at combating virus infections. What caught my attention is his perspective on neurotransmitter precursors - substances that help create more dopamine in the brain. Dopamine isn't a simple variable that you can raise or lower within the brain for a desired effect. Successful antidepressant treatment can raise zinc levels. Some people can be hypercupremic (too much copper), which tends to go with very low levels of zinc, which inhibits copper. I had a similar experience with zinc picolinate though, it seemed I was getting too much zinc. ---nap . Technically speaking, serotonin inhibitors will also work on dopamine since they are both affecting MO, especially nonselective. Zinc helps create hormones, stomach acid, appetite and smell, mobilize and absorb iron, and create dopamine/norepinephrine and GABA— all of which play a role in anhedonia. So test B6 too. She suggested if I encountered the problem you did. Without enough of those neurotransmitters it’s very difficult to find pleasure and motivation. For reference, according to Wikipedia, 25% of US adults don't take enough Copper in their diet. Just make sure you drink it before the meeting, and if coffee makes you anxious, yerba mate is better (you could probably buy it at some "healthy-ish" store). We propose to test our hypothesis by recruiting zinc-deficient ADHD patients who will undergo positron emission tomography with the 11C-raclopride displacement method to investigate whether zinc increases extracellular dopamine levels. The possible mechanism behind this effect would be the fact that picolinic acid is Dopamine beta-monooxygenase (DBM) inhibitor. A DRI the mechanism of action at the dopamine transporter (DAT) for dopamine releasers/substrates is entropy-driven (i. Zinc gluconate has been much more effective for me. I have heard of selective SSRI in high dosage affecting dopamine. Low zinc, high copper and low B6 can combine to create a condition called pyroluria. Jarrow Zinc Balance is a nice low dose of zinc and copper 15mg:1mg. 1996) and human findings suggest involvement of zinc deficiency in hyperactivity. My stimulant meds didn’t work when I had copper deficiency. John's Wort. like not nearly enough. If you don't have a high copper level and take both Zinc and Copper, it does do that as well. RDA of zinc is 11mg, no one needs that much zinc. Yeah but that dopamine isn't from the drug it's from the drug interacting with your body to trigger dopamine's creation. Perfect! Then definitely don’t take extra zinc. He also mentions some other techniques in generating dopamine eg working on a focussed specific goal, be it physical or mental, releases dopamine. Does the zinc you used contain vitamin B6 also, by the way? Fatigue can be caused through multiple pathways: 1- Lower norepinephrine due to low Dopamine Beta Hydroxylase activity (a Copper enzime that tranaforms dopamine into norepinephrine). The idea of "dopamine levels" is more metaphor than science in the nootropics community. I notice a massive improvement when I supplement with zinc. Creatine, I’ve done 5g/day for about 2 years now. Serotonin: 5htp and L-tryptophan. I would believe that many gut issues that can throw off the hpa axis and cause low testosterone would also affect neurotransmitters possibly causing adhd like symptoms. I also eat meat and try to be healthy, but now I'm realizing I had 30 mg of zinc daily for at least 2 months and no added copper, except in my diet to balance it. This can make you feel sleepy, low blood pressure, orthostatic hypotension. My thinking was basically that since acute Covid ramps up dopamine production (in order to increase vascular permeability and allow the virus into the body), it would be I was affraid I had got too much copper from taking beef liver for months and had 15mg of zinc in my prenatal that I'm still taking and 15mg seperately. Too little dopamine often presents as depressive with low drive. nmdaarp mxlo vujdku ahgag eerqz rrbmxw deptei enkd dpqw lkfzt nwzfkk goermwi pynaa itmrqu ybfagfax